Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.47 |
| ▸ | RORC | P51449 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 5/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597002 | 0.99 | THRB (0.47) | THRBRORCALDH1A1TSHRMEN1 | |
| SCHEMBL6775887 | 0.82 | THRB (0.36) | THRBALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL5328906 | 0.79 | THRB (0.48) | THRBRORCTHRA | |
| SCHEMBL282179 | 0.79 | THRB (0.56) | THRBRORCTHRA | |
| SCHEMBL282017 | 0.79 | THRB (0.53) | THRBRORCMEN1KMT2ATHRA | |
| SCHEMBL13913523 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRMEN1KMT2AHIF1A | |
| Hydrochloric Acid SCHEMBL8800518 | 0.78 | THRB (0.52) | THRBRORCMEN1KMT2ATHRA | |
| SCHEMBL5328904 | 0.77 | THRB (0.50) | THRBRORCTHRA | |
| SCHEMBL7590192 | 0.77 | ALDH1A1 (0.43) | THRBALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL282127 | 0.76 | THRB (0.57) | THRBRORCTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183074-A1 | SUBSTITUTED BIARYL ETHER COMPOUNDS | UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000072920-A1 | SUBSTITUTED BIARYL ETHER COMPOUNDS | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2000-12-07 | — | — | WO | disclosed |