Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 9/20 | 0.39 |
| ▸ | THRA | P10827 | 8/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114452 | 0.80 | THRB (0.50) | THRBTHRAGAA | |
| SCHEMBL666032 | 0.79 | THRB (0.43) | ALDH1A1THRBTHRAGAAALOX12 | |
| SCHEMBL6864460 | 0.79 | THRB (0.48) | ALDH1A1THRBTHRAMAPTKDM4E | |
| SCHEMBL282445 | 0.79 | THRB (0.49) | THRBTHRAALOX12 | |
| SCHEMBL13913523 | 0.77 | ALDH1A1 (0.54) | ALDH1A1TSHRMEN1KMT2AHIF1A | |
| SCHEMBL7555866 | 0.77 | THRB (0.47) | ALDH1A1TSHRMEN1KMT2ATHRB | |
| SCHEMBL667473 | 0.77 | THRB (0.45) | ALDH1A1TSHRMEN1KMT2ATHRB | |
| SCHEMBL7597002 | 0.76 | THRB (0.47) | ALDH1A1TSHRMEN1KMT2ATHRB | |
| SCHEMBL667776 | 0.73 | THRB (0.39) | ALDH1A1THRBTHRAHIF1AMAPT | |
| SCHEMBL6864242 | 0.73 | THRB (0.49) | THRBTHRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194422-A1 | BIARYL COMPOUNDS | UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000073292-A1 | BIARYL COMPOUNDS | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2000-12-07 | — | — | WO | disclosed |