Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812667 | 0.87 | MAPT (0.69) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6004947 | 0.86 | CYP1A2 (0.65) | SMN1; SMN2KMT2AMAPTLMNARAB9A | |
| SCHEMBL978809 | 0.85 | RAB9A (0.73) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL978808 | 0.85 | RAB9A (0.73) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6004332 | 0.84 | ALDH1A1 (0.54) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL11159531 | 0.84 | MAPT (0.62) | SMN1; SMN2KMT2AMAPTLMNARAB9A | |
| SCHEMBL2553087 | 0.83 | KMT2A (0.56) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL4993342 | 0.83 | KMT2A (0.56) | SMN1; SMN2KMT2AMAPTLMNARAB9A | |
| SCHEMBL9368595 | 0.83 | MEN1 (0.67) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL3359357 | 0.82 | LMNA (0.70) | SMN1; SMN2MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218352-A1 | BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE AND DOPAMINE RECEPTORS AFFINITY | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 2002-07-03 | — | — | EP | disclosed |
| US-6281218-B1 | USEFUL IN THE TREATMENT OF CNS DISORDERS. | INGELHEIM ITALIA S.P.A. (IT) | 2001-08-28 | — | — | US | disclosed |
| WO-2001021593-A1 | NEW BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE AND DOPAMINE RECEPTORS AFFINITY | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 2001-03-29 | — | — | WO | disclosed |