Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 12/20 | 0.55 |
| ▸ | NPC1 | O15118 | 10/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | STAT1 | P42224 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31040569 | 0.81 | TP53 (0.87) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL4893387 | 0.81 | TP53 (0.87) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL17084260 | 0.79 | TP53 (0.84) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL7523675 | 0.78 | RAB9A (0.59) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL7525489 | 0.78 | TP53 (0.59) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL14442613 | 0.76 | TP53 (0.84) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL29556598 | 0.74 | TP53 (0.70) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL22103808 | 0.74 | TP53 (0.74) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL6388689 | 0.73 | TP53 (0.73) | TP53TSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL7610775 | 0.73 | TP53 (0.73) | TP53TSHRALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |