Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 7/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777180 | 0.87 | PTGS2 (0.60) | MEN1GAAKMT2AGPBAR1PTGS2 | |
| SCHEMBL11893877 | 0.85 | ALDH1A1 (0.61) | MEN1GAAKMT2AGPBAR1PTGS2 | |
| SCHEMBL2723582 | 0.85 | GPBAR1 (0.62) | MEN1GAAKMT2AGPBAR1PTGS2 | |
| SCHEMBL11411843 | 0.83 | LMNA (0.61) | MEN1GAAKMT2AGPBAR1PTGS2 | |
| SCHEMBL4718673 | 0.82 | KMT2A (0.72) | MEN1GAAKMT2AGPBAR1PTGS2 | |
| SCHEMBL2775071 | 0.82 | GAA (0.64) | GAAGPBAR1PTGS2BACE1TSHR | |
| SCHEMBL903110 | 0.81 | KMT2A (1.00) | MEN1GAAKMT2ATSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL30684627 | 0.81 | KMT2A (0.70) | MEN1GAAKMT2AGPBAR1PTGS2 | |
| Hydrochloric Acid SCHEMBL30684473 | 0.80 | KMT2A (0.97) | MEN1GAAKMT2ATSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL30684542 | 0.80 | KMT2A (0.97) | MEN1GAAKMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226131-A2 | ISOXAZOLECARBOXAMIDE DERIVATIVES | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-07-31 | — | — | EP | claimed |
| WO-2001029015-A2 | ISOXAZOLECARBOXAMIDE DERIVATIVES AS ALPHA1-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 2001-04-26 | — | — | WO | claimed |