Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557848 | 0.92 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL226802 | 0.88 | CRHR1 (0.77) | CRHR1TDP1 | |
| SCHEMBL7557259 | 0.80 | CRHR1 (0.66) | CRHR1TDP1 | |
| SCHEMBL7554726 | 0.79 | CRHR1 (0.64) | CRHR1TDP1 | |
| SCHEMBL7554871 | 0.78 | CRHR1 (0.69) | CRHR1TDP1 | |
| SCHEMBL7563114 | 0.78 | CRHR1 (0.62) | CRHR1TDP1 | |
| SCHEMBL7554234 | 0.77 | CRHR1 (0.69) | CRHR1TDP1 | |
| SCHEMBL7960908 | 0.77 | CRHR1 (0.61) | CRHR1TDP1 | |
| SCHEMBL7556361 | 0.76 | CRHR1 (0.60) | CRHR1TDP1 | |
| SCHEMBL7560969 | 0.76 | CRHR1 (0.59) | CRHR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020019406-A1 | 9H-pyrimido[4,5-b]indole derivatives: CRF1 specific ligands | NEUROGEN CORPORATION | 2002-02-14 | — | — | US | claimed |
| US-6284766-B1 | DIAGNOSIS, THERAPY OF STRESS DISORDERS | NEUROGEN CORPORATION | 2001-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019406-A1 | 9H-pyrimido[4,5-b]indole derivatives: CRF1 specific ligands | HTR1D, CRHR1, HTR1A | CRHR1 2/4885TDP1 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.