Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 10/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218391 | 0.90 | ADRA1A (0.54) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL8659585 | 0.87 | ADRA1A (0.48) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6786820 | 0.87 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6715257 | 0.80 | MCHR1 (0.51) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6243274 | 0.77 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6793160 | 0.77 | ADRA1A (0.52) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6194820 | 0.77 | MAPT (0.47) | SMN1; SMN2MAPTALDH1A1GAAHPGD | |
| SCHEMBL7529263 | 0.76 | MCHR1 (0.46) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6269746 | 0.76 | ADRA1A (0.60) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6782745 | 0.76 | ADRA1A (0.52) | ADRA1DADRA1AADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020010186-A1 | Dihydropyrimidines and uses thereof | SYNAPTIC PHARMACEUTICAL CORPORATION | 2002-01-24 | — | — | US | disclosed |
| EP-0790826-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0790826-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010186-A1 | Dihydropyrimidines and uses thereof | QDPR, DPYD, ADRA1D | ADRA1D 3/4885ADRA1A 4/4885ADRA1B 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.