Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28378342 | 0.77 | CES1 (0.47) | CES1LMNAKDM4EMAPTALOX15 | |
| SCHEMBL70455 | 0.73 | CES1 (0.56) | CES1LMNAKDM4EMAPTHTT | |
| SCHEMBL8058005 | 0.73 | LMNA (0.44) | LMNAKDM4ETDP1MAPTHTT | |
| SCHEMBL26613646 | 0.72 | KDM4E (0.47) | LMNAKDM4ETDP1MAPTHTT | |
| SCHEMBL380656 | 0.72 | CES1 (1.00) | CES1LMNAKDM4ETDP1MAPT | |
| Phenanthroline SCHEMBL417111 | 0.70 | LMNA (0.73) | LMNAKDM4ETDP1MAPTHTT | |
| SCHEMBL21096502 | 0.70 | KDM4E (0.48) | LMNAKDM4ETDP1MAPTHTT | |
| Phenanthroline SCHEMBL8685731 | 0.69 | CCR1 (0.89) | LMNAKDM4ETDP1MAPTHTT | |
| Phenanthroline SCHEMBL30451276 | 0.69 | CCR1 (0.89) | LMNAKDM4ETDP1MAPTHTT | |
| Phenanthroline SCHEMBL8722750 | 0.69 | KDM4E (0.70) | LMNAKDM4ETDP1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946477-B1 | DERIVATIVES OF 9,9-DIFLUORO-9,10-DIHYDROPHENANTHRENE FOR LIQUID CRYSTAL MIXTURES | AVENTIS RES & TECHNOLOGY GMBH (DE) | 2002-07-31 | — | — | EP | disclosed |
| EP-0946473-B1 | FLUORINATED PHENANTRENE DERIVATIVES FOR LIQUID CRYSTAL MIXTURES | AVENTIS RES & TECHNOLOGY GMBH (DE) | 2002-07-31 | — | — | EP | disclosed |
| US-6168838-B1 | FOR FERROELECTRIC SWITCHING AND/OR DISPLAY DEVICE | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO. KG (DE) | 2001-01-02 | — | — | US | disclosed |
| EP-0946477-A1 | DERIVATIVES OF 9,9-DIFLUORO-9,10-DIHYDROPHENANTHRENE FOR LIQUID CRYSTAL MIXTURES | Aventis Research & Technologies GmbH & Co. KG. (DE) | 1999-10-06 | — | — | EP | disclosed |
| EP-0946473-A1 | FLUORINATED PHENANTRENE DERIVATIVES FOR LIQUID CRYSTAL MIXTURES | Aventis Research & Technologies GmbH & Co. KG. (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027035-A1 | FLUORINATED PHENANTRENE DERIVATIVES FOR LIQUID CRYSTAL MIXTURES | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO KG (DE) | 1998-06-25 | — | — | WO | disclosed |
| WO-1998027043-A1 | DERIVATIVES OF 9,9-DIFLUORO-9,10-DIHYDROPHENANTHRENE FOR LIQUID CRYSTAL MIXTURES | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO. KG (DE) | 1998-06-25 | — | — | WO | disclosed |
| US-5434264-A | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-18 | — | — | US | disclosed |
| US-5300642-A | α, α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0311010-B1 | Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | DU PONT MERCK PHARMA (US) | 1994-02-02 | — | — | EP | disclosed |
| EP-0532054-A1 | Process for preparing alpha,alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-5173489-A | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DUPONT MERCK PHARMACEUTICAL CO. (US) | 1992-12-22 | — | — | US | disclosed |
| EP-0311010-A2 | Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-04-12 | — | — | EP | disclosed |