Sugi Predict

Sugi Predict / Compounds / SCHEMBL286942

SCHEMBL286942

SCHEMBL286942

O=C(O)c1ccc(Br)c(F)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.53
▸ LMNA P02545 2/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ RAB9A P51151 1/20 0.53
▸ TSHR P16473 2/20 0.46
▸ TP53 P04637 1/20 0.46
▸ KDM4E B2RXH2 2/20 0.45
▸ TTR P02766 2/20 0.45
▸ CA12 O43570 1/20 0.45
▸ CA1 P00915 1/20 0.45
▸ CA2 P00918 1/20 0.45
▸ POLB P06746 1/20 0.45
▸ GAA P10253 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ CA4 P22748 1/20 0.45
▸ CA6 P23280 1/20 0.45
▸ PTGS2 P35354 1/20 0.45
▸ CA7 P43166 1/20 0.45
▸ CA9 Q16790 1/20 0.45
▸ CA14 Q9ULX7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30523532 1.00 HTT (0.53) HTTLMNAMAPK1RAB9ATSHR
SCHEMBL7559862 0.89 HTT (0.49) HTTLMNAMAPK1RAB9AKDM4E
SCHEMBL7694625 0.86 RARB (0.44) HTTLMNAMAPK1RAB9ATSHR
SCHEMBL23215775 0.85 SRD5A2 (0.46) HTTLMNAMAPK1RAB9ATSHR
SCHEMBL104151 0.83 TTR (0.50) HTTLMNAMAPK1RAB9ATSHR
SCHEMBL31302316 0.83 TTR (0.50) HTTLMNAMAPK1RAB9ATSHR
Bromide SCHEMBL11166294 0.81 TTR (0.48) HTTLMNAMAPK1RAB9ATSHR
SCHEMBL321581 0.81 CES2 (0.43) HTTLMNAMAPK1RAB9ATSHR
SCHEMBL333891 0.81 ALDH1A1 (0.47) RAB9AMAPTCES2CES1HPGD
SCHEMBL356759 0.81 KIF11 (0.49) MAPK1TSHRCA2CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1301 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120118467-A Waterproof corrosion-resistant floating cable 西隆电缆有限公司 2025-06-10 — — CN claimed
CN-113956160-A Preparation method of flurbiprofen impurity F 北京茗泽中和药物研究有限公司 2022-01-21 — — CN claimed
US-12622909-B2 Allosteric EGFR inhibitors and methods of use thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-05-12 — — US disclosed
US-20260125367-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS REMEDY PLAN, INC. (US) 2026-05-07 — — US disclosed
US-12617783-B2 Heterocyclic GLP-1R agonists BIOMEA FUSION, INC. (US) 2026-05-05 — — US disclosed
US-20260085064-A1 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF KARYOPHARM THERAPEUTICS INC (US) 2026-03-26 — — US disclosed
EP-4041732-B1 ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR ZHEJIANG METON PHARMACEUTICAL CO LTD (CN) 2026-03-18 — — EP disclosed
EP-3858833-B9 AMINONORBORNANE DERIVATIVE AND MANUFACTURE METHOD THEREOF AND USE THEREOF TRANSTHERA SCIENCES NANJING INC (CN) 2026-03-11 — — EP disclosed
US-12570625-B2 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof NOVARTIS AG (CH) 2026-03-10 — — US disclosed
EP-4703358-A1 BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF China Pharmaceutical University (CN) 2026-03-04 — — EP disclosed
US-12559506-B2 Indazole based compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-24 — — US disclosed
EP-0560482-B1 4-Benzoyl isoxazole derivatives and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1997-08-06 — — EP disclosed
US-5650533-A Intermediates to herbicidal 4-substituted isoxazoles RHONE-POULENC AGRICULTURE LTD. (GB) 1997-07-22 — — US disclosed
EP-0682659-B1 4-Benzoyl isoxazole derivatives, their preparation and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1997-04-16 — — EP disclosed
EP-0682659-A1 4-BENZOYL ISOXAZOLES AND THEIR USE AS HERBICIDES. RHONE POULENC AGRICULTURE (GB) 1995-11-22 — — EP disclosed
WO-1994018179-A1 4-BENZOYL ISOXAZOLES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE LTD (GB) 1994-08-18 — — WO disclosed
US-5334753-A Lithiating halobenzoic acid, then reacting with electrophilic reagent RHONE-POULENC AGRICULTURE LTD (GB) 1994-08-02 — — US disclosed
EP-0560482-A1 4-Benzoyl isoxazoles derivatives and their use as herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1993-09-15 — — EP disclosed
CN-1076194-A Weedicide RHONE POULENC AGRICULTURE (GB) 1993-09-15 — — CN disclosed
US-3953595-A Substituted benzoic acid hypolipemic agents PFIZER INC. (US) 1976-04-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12617783-B2 Heterocyclic GLP-1R agonists GLP1R, GIPR, GPR119 HTT 2184/4885LMNA 4045/4885MAPK1 1599/4885
US-12622909-B2 Allosteric EGFR inhibitors and methods of use thereof EGFR, ERBB3, ERBB2 HTT 3361/4885LMNA 4706/4885MAPK1 354/4885
US-12570625-B2 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof IKZF1, IKZF2, BCL6 HTT 2692/4885LMNA 952/4885MAPK1 2820/4885
US-12559506-B2 Indazole based compounds and associated methods of use LRRK2, CRBN, CLK2 HTT 441/4885LMNA 1596/4885MAPK1 1600/4885
US-20260125367-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS MCL1, MALT1, BCL6 HTT 2140/4885LMNA 2021/4885MAPK1 3373/4885
US-20260085064-A1 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF BCL6, MALT1, BCL6B HTT 57/4885LMNA 1171/4885MAPK1 3250/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.