Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.58 |
| ▸ | HPGD | P15428 | 7/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | EED | O75530 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | CASP1 | P29466 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10408359 | 0.76 | KMT2A (0.56) | KDM4EHSD17B10HPGDTSHRALDH1A1 | |
| SCHEMBL9536836 | 0.75 | KCNH3 (0.47) | KDM4EHSD17B10HPGDTSHRALDH1A1 | |
| SCHEMBL3475619 | 0.74 | KDM4E (1.00) | KDM4EHSD17B10HPGDTSHRHTR6 | |
| SCHEMBL10144182 | 0.74 | HPGD (0.45) | KDM4EHPGDTSHRHTR6EED | |
| SCHEMBL30607653 | 0.73 | TSHR (0.66) | KDM4EHSD17B10HPGDTSHRHTR6 | |
| SCHEMBL22129202 | 0.72 | KDM4E (0.54) | KDM4EHSD17B10HPGDTSHREED | |
| SCHEMBL7519734 | 0.71 | KDM4E (0.61) | KDM4EHSD17B10HPGDTSHREED | |
| SCHEMBL874328 | 0.71 | ALDH1A1 (0.46) | KDM4EHSD17B10HPGDTSHRALDH1A1 | |
| SCHEMBL31704166 | 0.70 | CISD1 (0.69) | KDM4EHSD17B10TSHRHTR6ALDH1A1 | |
| SCHEMBL31704312 | 0.70 | APP (0.55) | KDM4EHSD17B10HPGDTSHRHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020193389-A1 | Method of inhibiting neoplastic cells with imidazoquinazoline derivatives | OSI PHARMACEUTICALS, INC. | 2002-12-19 | — | — | US | disclosed |
| US-6127541-A | 8-((DISUBSTITUTED AMINO)BENZYLAMINO)-2,3-DIHYDRO-1H-IMIDAZO(4,5-G)QUINAZOLINE-(2-THIONE OR 2-ONE); SELECTIVE CYCLIC GUANOSINE 3',5' MONOPHOSPHATE (CGMP)--SPECIFIC PHOSPHODIESTERASE (PDE) INHIBITORY ACTIVITY | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-10-03 | — | — | US | disclosed |
| CN-1205008-A | Imidazoquinazoline derivatives | KYOWA HAKKO KOGYO KK (JP) | 1999-01-13 | — | — | CN | disclosed |
| EP-0863144-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | Kyowa Hakko Co., Ltd. (JP) | 1998-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193389-A1 | Method of inhibiting neoplastic cells with imidazoquinazoline derivatives | MKI67, HRAS, VHL | KDM4E 2757/4885HSD17B10 3685/4885HPGD 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.