SCHEMBL7560036

SCHEMBL7560036

N#CCNC(=O)C(F)CCCCNC(=O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 1/20 0.52
CTSL P07711 8/20 0.50
CTSS P25774 7/20 0.50
CTSB P07858 7/20 0.50
CTSK P43235 5/20 0.50
HDAC3 O15379 3/20 0.49
HDAC4 P56524 3/20 0.49
HDAC1 Q13547 3/20 0.49
HDAC7 Q8WUI4 3/20 0.49
HDAC2 Q92769 3/20 0.49
HDAC10 Q969S8 3/20 0.49
HDAC11 Q96DB2 3/20 0.49
HDAC8 Q9BY41 3/20 0.49
HDAC6 Q9UBN7 3/20 0.49
HDAC9 Q9UKV0 3/20 0.49
HDAC5 Q9UQL6 3/20 0.49
EPHX2 P34913 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
CTSV O60911 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5527601 0.80 EPHX2 (0.54) NAAACTSLCTSSCTSBCTSK
SCHEMBL5525754 0.79 HDAC6 (0.65) NAAAHDAC3HDAC4HDAC1HDAC7
SCHEMBL10453239 0.78 HDAC6 (0.64) NAAAHDAC3HDAC4HDAC1HDAC7
SCHEMBL6184062 0.77 HDAC6 (0.68) NAAAHDAC3HDAC4HDAC1HDAC7
SCHEMBL5524028 0.77 HDAC6 (0.68) NAAAHDAC3HDAC4HDAC1HDAC7
SCHEMBL4633788 0.77 NPC1 (0.60) NAAAHDAC3HDAC4HDAC1HDAC7
SCHEMBL2863808 0.77 GAA (0.61) NAAACTSLCTSSCTSBCTSK
SCHEMBL5529197 0.76 EPHX2 (0.60) CTSLCTSSCTSBCTSKEPHX2
SCHEMBL5526376 0.76 EPHX2 (0.52) NAAACTSLCTSSCTSBCTSK
SCHEMBL12650598 0.76 NAAA (0.66) NAAAHDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1178958-A2 N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-02-13 EP disclosed
WO-2000055125-A2 N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2000-09-21 WO disclosed