Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846767 | 0.84 | HDAC6 (0.47) | KMT2AKCNK3KCNK9MEN1TLR7 | |
| SCHEMBL4508472 | 0.77 | CES2 (0.64) | KMT2ASMN1; SMN2MEN1TLR7GRM4 | |
| SCHEMBL28727383 | 0.75 | CES2 (0.61) | KMT2ASMN1; SMN2MEN1TLR7GRM4 | |
| Water SCHEMBL30018403 | 0.69 | ALDH1A1 (0.59) | KMT2ASMN1; SMN2TLR7HDAC6KDM4E | |
| SCHEMBL8597610 | 0.69 | LMNA (0.61) | KMT2ASMN1; SMN2KCNK3KCNK9TLR7 | |
| SCHEMBL917323 | 0.68 | HDAC6 (0.57) | KMT2ASMN1; SMN2KCNK3KCNK9TLR7 | |
| SCHEMBL3188677 | 0.68 | ALDH1A1 (0.62) | KMT2ASMN1; SMN2MEN1TLR7HDAC6 | |
| SCHEMBL30037891 | 0.67 | ALDH1A1 (0.61) | KMT2ASMN1; SMN2TLR7HDAC6KDM4E | |
| SCHEMBL162189 | 0.67 | ALDH1A1 (0.61) | KMT2ASMN1; SMN2TLR7HDAC6KDM4E | |
| SCHEMBL1147702 | 0.67 | KDM4E (0.73) | SMN1; SMN2TLR7KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001068605-A1 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED BENZENES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |