SCHEMBL917323

SCHEMBL917323

NC(=O)NC(=O)c1ccccn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.57
HDAC3 O15379 1/20 0.57
HDAC4 P56524 1/20 0.57
HDAC1 Q13547 1/20 0.57
HDAC7 Q8WUI4 1/20 0.57
HDAC2 Q92769 1/20 0.57
HDAC10 Q969S8 1/20 0.57
HDAC11 Q96DB2 1/20 0.57
HDAC8 Q9BY41 1/20 0.57
HDAC9 Q9UKV0 1/20 0.57
HDAC5 Q9UQL6 1/20 0.57
CES2 O00748 1/20 0.55
CES1 P23141 1/20 0.55
GRM4 Q14833 3/20 0.54
LMNA P02545 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
NAPRT Q6XQN6 1/20 0.53
P4HTM Q9NXG6 1/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
NPC1 O15118 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4508472 0.88 CES2 (0.64) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL28727383 0.86 CES2 (0.61) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL8597610 0.82 LMNA (0.61) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL21792059 0.81 CES2 (0.52) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL3188677 0.81 ALDH1A1 (0.62) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL8779235 0.80 SMYD3 (0.54) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL109657 0.80 HDAC3 (0.61) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL7989152 0.80 HDAC1 (0.77) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL28131851 0.80 HDAC3 (0.61) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL2747054 0.80 ALDH1A1 (0.51) HDAC6HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190157599-A1 THIN FILM AND ORGANIC ELECTROLUMINESCENT ELEMENT MERCK PATENT GMBH (DE) 2019-05-23 US disclosed
EP-1887416-B1 ELECTROCHROMIC DISPLAY ELEMENT AND FULL-COLOR ELECTROCHROMIC DISPLAY ELEMENT KONICA MINOLTA HOLDINGS INC (JP) 2015-09-02 EP disclosed
US-8765309-B2 Electrochemical device KONICA MINOLTA HOLDINGS, INC. (JP) 2014-07-01 US disclosed
US-8437067-B2 Electrochemical display element KONICA MINOLTA HOLDINGS, INC. (JP) 2013-05-07 US disclosed
US-20110266945-A1 DISPLAY ELEMENT KONICA MINOLTA HOLDINGS, INC. (JP) 2011-11-03 US disclosed
US-20110143211-A1 ELECTROCHEMICAL DEVICE KONICA MINOLTA HOLDINGS, INC. (JP) 2011-06-16 US disclosed
US-20110058244-A1 ELECTROCHROMIC DISPLAY ELEMENT KONICA MINOLTA HOLDINGS, INC. (JP) 2011-03-10 US disclosed
US-20110019265-A1 DISPLAY ELEMENT AND METHOD OF FORMING POROUS LAYER IN DISPLAY ELEMENT KONICA MINOLTA HOLDINGS, INC. (JP) 2011-01-27 US disclosed
US-20110013261-A1 ELECTROCHEMICAL DISPLAY ELEMENT KONICA MINOLTA HOLDINGS, INC. (JP) 2011-01-20 US disclosed
US-20100097684-A1 DISPLAY ELEMENT KONICA MINOLTA HOLDINGS, INC. (JP) 2010-04-22 US disclosed
US-7005251-B2 Silver salt photothermographic dry imaging material, image recording method and image forming method for the same KONICA MINOLTA HOLDINGS, INC. (JP) 2006-02-28 US disclosed
US-20040115569-A1 Photothermographic imaging material and method for forming image KONICA MINOLTA HOLDINGS, INC. (JP) 2004-06-17 US disclosed
US-20040106074-A1 Silver salt photothermographic dry imaging material, image recording method and image forming method for the same KONICA MINOLTA HOLDINGS, INC. (JP) 2004-06-03 US disclosed
US-20040101794-A1 Photothermographic imaging material KONICA MINOLTA HOLDINGS, INC. (JP) 2004-05-27 US disclosed
EP-1422552-A2 Silver salt photothermographic dry imaging material, image recording method and image forming method for the same KONICA MINOLTA HOLDINGS, INC. (JP) 2004-05-26 EP disclosed
US-5340707-A Containing specified pyrazolone dye; storage stability KONICA CORPORATION (JP) 1994-08-23 US disclosed
US-5106843-A Treatment of migraine, emesis, anxiety, gastrointestinal disorders, psychological disorders AMERICAN HOME PRODUCTS CORPORATION (US) 1992-04-21 US disclosed
EP-0323077-B1 HETEROCYCLIC COMPOUNDS JOHN WYETH & BROTHER LIMITED (GB) 1991-09-11 EP disclosed
US-4983600-A Antiemetics, antianxiety agents, gastrointestinal disorders JOHN WYETH & BROTHER LIMITED (GB) 1991-01-08 US disclosed
EP-0323077-A1 Heterocyclic compounds JOHN WYETH & BROTHER LIMITED (GB) 1989-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190157599-A1 THIN FILM AND ORGANIC ELECTROLUMINESCENT ELEMENT ETFA, EEA1, EEF1A1 HDAC6 4102/4885HDAC3 4838/4885HDAC4 4206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.