Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623486 | 0.81 | KDM4E (0.46) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL1302985 | 0.81 | KDM4E (0.46) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL16118521 | 0.81 | KDM4E (0.46) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL477109 | 0.81 | DYRK1A (0.53) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL20033886 | 0.81 | KDM4E (0.46) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL3357291 | 0.81 | KDM4E (0.46) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL1243656 | 0.81 | ALDH1A1 (0.45) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL3086598 | 0.78 | AHR (0.39) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL297697 | 0.78 | DRD2 (0.52) | KDM4EDRD2DRD4DRD3HTR1A | |
| SCHEMBL3951145 | 0.78 | KDM4E (0.40) | KDM4EDRD2DRD4DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250179092-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-06-05 | — | — | US | disclosed |
| EP-4490162-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-01-15 | — | — | EP | disclosed |
| CN-118843634-A | Pyrido [1,2-a ] pyrimidin-4-one derivatives | 豪夫迈·罗氏有限公司 | 2024-10-25 | — | — | CN | disclosed |
| WO-2023170115-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-09-14 | — | — | WO | disclosed |
| US-9617271-B2 | Triazolo compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-04-11 | — | — | US | disclosed |
| EP-2916842-B1 | TRIAZOLO COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-10-19 | — | — | EP | disclosed |
| EP-2916842-A1 | TRIAZOLO COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-09-16 | — | — | EP | disclosed |
| US-20150232472-A1 | TRIAZOLO COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-08-20 | — | — | US | disclosed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |
| WO-2014072261-A1 | TRIAZOLO COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-15 | — | — | WO | disclosed |
| US-20050032650-A1 | Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-02-10 | — | — | US | disclosed |
| EP-1466527-A1 | FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME | Sumitomo Chemical Takeda Agro Company, Limited (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-1997011075-A1 | TRIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-27 | — | — | WO | disclosed |
| EP-0381132-B1 | Imidazopyridazines, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0238070-B1 | Sulfonylurea compounds, their production and herbicidal use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1993-12-29 | — | — | EP | disclosed |
| US-5202324-A | Bronchodilators | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| US-5155108-A | Imidazopyridazines and use as antiasthmatic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-5017212-A | For rice paddies | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0381132-A1 | Imidazopyridazines, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |
| EP-0238070-A2 | Sulfonylurea compounds, their production and herbicidal use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232472-A1 | TRIAZOLO COMPOUNDS | GRIK5, NLN, GRIN2C | KDM4E 4142/4885DRD2 1242/4885DRD4 1391/4885 |
| US-20250179092-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | ADORA1, P2RY1, CCNA1 | KDM4E 3894/4885DRD2 236/4885DRD4 197/4885 |
| US-20050032650-A1 | Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same | NOTUM, WEE1, DDT | KDM4E 683/4885DRD2 1082/4885DRD4 1741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.