Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 9/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 8/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.33 |
| ▸ | ITGAV | P06756 | 4/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.33 |
| ▸ | ITGAL | P20701 | 2/20 | 0.33 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3182383 | 0.79 | ACE (0.38) | ITGB1ITGA4POLBL3MBTL1 | |
| SCHEMBL3182376 | 0.79 | ACE (0.38) | ITGB1ITGA4POLBL3MBTL1 | |
| SCHEMBL6233244 | 0.79 | ACE (0.38) | ITGB1ITGA4POLBL3MBTL1 | |
| SCHEMBL248703 | 0.76 | MME (0.43) | ITGB1ITGA5ITGA4RIPK1POLB | |
| SCHEMBL6967928 | 0.76 | ITGB1 (0.37) | ITGB1ITGA5ITGA4BRD4ITGB3 | |
| SCHEMBL6967927 | 0.76 | ITGB1 (0.37) | ITGB1ITGA5ITGA4BRD4ITGB3 | |
| SCHEMBL7386119 | 0.74 | ITGB1 (0.51) | ITGB1ITGA5ITGA4RIPK1POLB | |
| SCHEMBL6686977 | 0.74 | POLB (0.36) | ITGB1ITGA5ITGA4POLB | |
| SCHEMBL7680021 | 0.74 | ITGB1 (0.51) | ITGB1ITGA5ITGA4RIPK1POLB | |
| SCHEMBL6972069 | 0.74 | HRH3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187809-A1 | PROCESS FOR REDUCTION OF (2R)-4-OXOAZETIDINONE-2-CARBOXYLIC ACID | ABBOTT LABORATORIES (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000076964-A1 | PROCESS FOR REDUCTION OF (2R)-4-OXOAZETIDINONE-2-CARBOXYLIC ACID | ABBOTT LABORATORIES (US) | 2000-12-21 | — | — | WO | disclosed |
| US-6103911-A | Process for reduction of (2R)-4-oxoazetidinone-2-carboxylic acid | ABBOTT LABORATORIES (US) | 2000-08-15 | — | — | US | disclosed |