Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27545966 | 0.80 | NOTUM (0.49) | NOTUMKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL9802357 | 0.80 | NOTUM (0.40) | NOTUMKDM4EMAPTALDH1A1KDM1A | |
| Bromide SCHEMBL9694485 | 0.78 | NOTUM (0.39) | NOTUMKDM4EMAPTALDH1A1KDM1A | |
| SCHEMBL1106902 | 0.77 | CYP2D6 (0.39) | KDM1AHPGDSMN1; SMN2POLB | |
| SCHEMBL3969979 | 0.76 | NOTUM (0.56) | NOTUMKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL19157294 | 0.72 | NOTUM (0.51) | NOTUMKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL3969974 | 0.72 | NOTUM (0.51) | NOTUMKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL3315465 | 0.72 | NOTUM (0.51) | NOTUMKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL12570386 | 0.72 | NOTUM (0.51) | NOTUMKDM4EMAPTALDH1A1KDM1A | |
| SCHEMBL12649500 | 0.72 | POLB (0.52) | NOTUMKDM4EMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022272060-A1 | EP2 ANTAGONIST COMPOUNDS | RESERVOIR NEUROSCIENCE, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9447103-B2 | Inauhzin analogues that induce P53, inhibit cell growth, and have antitumor activity | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
| US-20150197522-A1 | INAUHZIN ANALOGUES THAT INDUCE P53, INHIBIT CELL GROWTH, AND HAVE ANTITUMOR ACTIVITY | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) | 2015-07-16 | — | — | US | disclosed |
| US-20150197522-A1 | INAUHZIN ANALOGUES THAT INDUCE P53, INHIBIT CELL GROWTH, AND HAVE ANTITUMOR ACTIVITY | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) | 2015-07-16 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8067607-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20100108997-A1 | Novel organic electroluminescent compounds and organic electroluminescent device using the same | GRACEL DISPLAY INC. (KR) | 2010-05-06 | — | — | US | disclosed |
| US-20100108997-A1 | Novel organic electroluminescent compounds and organic electroluminescent device using the same | GRACEL DISPLAY INC. (KR) | 2010-05-06 | — | — | US | disclosed |
| US-20100004229-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2010-01-07 | — | — | US | disclosed |
| US-20070021509-A1 | Phosphate transport inhibitors | JOZEFIAK THOMAS H | 2007-01-25 | — | — | US | disclosed |
| WO-2002020498-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF 3,4-DIHYDRO-1,4-BENZOTHIAZINE | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | NOTUM 3529/4885KDM4E 465/4885MAPT 3833/4885 |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, MDH1 | NOTUM 1501/4885KDM4E 1908/4885MAPT 2356/4885 |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | NOTUM 3529/4885KDM4E 465/4885MAPT 3833/4885 |
| US-20100108997-A1 | Novel organic electroluminescent compounds and organic electroluminescent device using the same | OR10J3, OCIAD1, OCIAD2 | NOTUM 1648/4885KDM4E 2780/4885MAPT 3478/4885 |
| US-20070021509-A1 | Phosphate transport inhibitors | SLC34A2, SLC34A1, SLC20A1 | NOTUM 2402/4885KDM4E 4457/4885MAPT 3058/4885 |
| US-20100004229-A1 | Potassium Channel Inhibitors | KCNJ2, KCNH2, KCNH3 | NOTUM 3309/4885KDM4E 418/4885MAPT 2186/4885 |
| US-20150197522-A1 | INAUHZIN ANALOGUES THAT INDUCE P53, INHIBIT CELL GROWTH, AND HAVE ANTITUMOR ACTIVITY | TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NOP58 | NOTUM 1717/4885KDM4E 4482/4885MAPT 3443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.