Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 3/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29630883 | 0.86 | TRPV4 (0.52) | CYP11B2CYP11B1TRPV4ALDH1A1SMN1; SMN2 | |
| SCHEMBL923510 | 0.86 | TRPV4 (0.52) | CYP11B2CYP11B1TRPV4ALDH1A1SMN1; SMN2 | |
| SCHEMBL3164050 | 0.86 | CYP11B1 (0.58) | CYP11B2CYP11B1DAOTRPV4S1PR3 | |
| SCHEMBL7871724 | 0.77 | CYP11B1 (0.50) | CYP11B2CYP11B1DAOTRPV4S1PR3 | |
| SCHEMBL2724753 | 0.76 | TRPV4 (0.53) | CYP11B2CYP11B1DAOTRPV4KCNJ1 | |
| SCHEMBL6745175 | 0.75 | TRPV4 (0.40) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL6061330 | 0.73 | KIF11 (0.54) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL31674269 | 0.73 | APP (0.46) | TRPV4CACNA1H | |
| SCHEMBL287322 | 0.73 | TRPV4 (0.53) | CYP11B2CYP11B1DAOTRPV4KCNJ1 | |
| SCHEMBL32683774 | 0.72 | HDAC1 (0.39) | CYP11B2CYP11B1DAOTRPV4CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002079147-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002078702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-10-10 | — | — | WO | disclosed |
| WO-2001051126-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| WO-2000034437-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-06-15 | — | — | WO | disclosed |