Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 2/20 | 0.70 |
| ▸ | ADRA2A known ✓ | P08913 | 5/20 | 0.40 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 0.40 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.70 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.70 |
| ▸ | C1R | P00736 | 1/20 | 0.70 |
| ▸ | F10 | P00742 | 1/20 | 0.70 |
| ▸ | KLK1 | P06870 | 1/20 | 0.70 |
| ▸ | F12 | P00748 | 1/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.62 |
| ▸ | PTGIR | P43119 | 5/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.37 |
| ▸ | PLAU | P00749 | 3/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561463 | 0.93 | PRSS1 (0.69) | PRSS1F2KLKB1C1RF10 | |
| Hydrochloric Acid SCHEMBL7584502 | 0.90 | PRSS1 (0.67) | PRSS1F2KLKB1C1RF10 | |
| SCHEMBL7598149 | 0.88 | PRSS1 (0.73) | PRSS1F2KLKB1C1RF10 | |
| Hydrochloric Acid SCHEMBL7591940 | 0.85 | PRSS1 (0.66) | PRSS1F2KLKB1C1RF10 | |
| Hydrochloric Acid SCHEMBL7563597 | 0.82 | PRSS1 (0.60) | PRSS1F2KLKB1C1RF10 | |
| SCHEMBL7562225 | 0.82 | FTO (0.46) | PRSS1F2KLKB1C1RF10 | |
| Sepimostat SCHEMBL29406588 | 0.82 | PRSS1 (1.00) | PRSS1F2KLKB1C1RF10 | |
| Sepimostat SCHEMBL1228902 | 0.82 | PRSS1 (1.00) | PRSS1F2KLKB1C1RF10 | |
| Sepimostat SCHEMBL15536391 | 0.82 | PRSS1 (1.00) | PRSS1F2KLKB1C1RF10 | |
| Hydrochloric Acid SCHEMBL7563216 | 0.82 | PRSS1 (0.68) | PRSS1F2KLKB1C1RF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802179-B1 | SUBSTITUTED AMIDINONAPHTHYL ESTER DERIVATIVES | TORII PHARMACEUTICAL CO LTD (JP) | 2002-08-21 | — | — | EP | disclosed |
| US-5885990-A | FIBRINOLYSIS PROMOTING ACTION; THROMBOLYSIS ACTION | TORII PHARMACEUTICAL CO., LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0802179-A1 | SUBSTITUTED AMIDINONAPHTHYL ESTER DERIVATIVES | TORII PHARMACEUTICAL CO., LTD. (JP) | 1997-10-22 | — | — | EP | disclosed |