Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Sepimostat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 2/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 4/20 | 0.48 |
| ▸ | ADRA2C known ✓ | P18825 | 4/20 | 0.48 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.48 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.47 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.47 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.47 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.47 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 1.00 |
| ▸ | C1R | P00736 | 2/20 | 1.00 |
| ▸ | F10 | P00742 | 2/20 | 1.00 |
| ▸ | KLK1 | P06870 | 2/20 | 1.00 |
| ▸ | KLKB1 | P03952 | 1/20 | 1.00 |
| ▸ | F12 | P00748 | 4/20 | 0.91 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.91 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sepimostat SCHEMBL29406588 | 1.00 | PRSS1 (1.00) | PRSS1F2C1RF10KLK1 | |
| Sepimostat SCHEMBL1228902 | 1.00 | PRSS1 (1.00) | PRSS1F2C1RF10KLK1 | |
| Sepimostat SCHEMBL872319 | 0.95 | F12 (1.00) | PRSS1F2C1RF10KLK1 | |
| Sepimostat SCHEMBL9825206 | 0.94 | F12 (0.98) | PRSS1F2C1RF10KLK1 | |
| SCHEMBL7598149 | 0.84 | PRSS1 (0.73) | PRSS1F2C1RF10KLK1 | |
| SCHEMBL10035205 | 0.83 | PRSS1 (0.74) | PRSS1F2C1RF10KLK1 | |
| SCHEMBL7563393 | 0.82 | PRSS1 (0.70) | PRSS1F2C1RF10KLK1 | |
| SCHEMBL7561463 | 0.82 | PRSS1 (0.69) | PRSS1F2C1RF10KLK1 | |
| Hydrochloric Acid SCHEMBL7563216 | 0.79 | PRSS1 (0.68) | PRSS1F2C1RF10KLK1 | |
| Nafamostat SCHEMBL564665 | 0.78 | FTO (0.70) | PRSS1F2C1RF10KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113390231-B | Production device and production process for producing ultrapure oxygen and liquid nitrogen by adopting precooling system | 河南心连心深冷能源股份有限公司 | 2025-02-28 | — | — | CN | claimed |
| CN-119503739-A | Method for preparing aluminum nitride by using crude aluminum indirect nitrogen nitriding | 中铝科学技术研究院有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-118829728-A | Oligonucleotide modulators that activate dystrophin-related protein expression | 中美瑞康核酸技术(南通)研究院有限公司 | 2024-10-22 | — | — | CN | claimed |
| CN-113390231-B | Production device and production process for producing ultrapure oxygen and liquid nitrogen by adopting precooling system | 河南心连心深冷能源股份有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119503739-A | Method for preparing aluminum nitride by using crude aluminum indirect nitrogen nitriding | 中铝科学技术研究院有限公司 | 2025-02-25 | — | — | CN | disclosed |
| CN-118829728-A | Oligonucleotide modulators that activate dystrophin-related protein expression | 中美瑞康核酸技术(南通)研究院有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-118772276-A | Nkp 46-46 binding agent | 依奈特制药公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-118715277-A | Melt-processible cellulose ester compositions, melts and melt-formed articles made therefrom | 伊士曼化工公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-110300765-B | Nkp 46-46 binding agent | 依奈特制药公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-118361665-A | Fuel gas supply flow rate adjusting method, device, equipment and storage medium | 万华化学集团股份有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-117377864-A | Detection lens and detection method for head-mounted display device | 歌尔光学科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-116970771-A | Electromagnetic coupling cryogenic treatment equipment | 太原科技大学 | 2023-10-31 | — | — | CN | disclosed |
| CN-116640785-A | Recombinant gene cluster and application thereof in promoting symbiotic nitrogen-fixing bacteria biofilm formation | 安徽微壤生物科技有限公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-116406320-A | Ultrafast flash joule heating synthesis method and system for implementing same | 威廉马什赖斯大学 | 2023-07-07 | — | — | CN | disclosed |
| CN-116390819-A | Ultrafast flash joule heating synthesis method and system for implementing same | 威廉马什赖斯大学 | 2023-07-04 | — | — | CN | disclosed |
| CN-115588847-A | Antenna gain amplifier based on Fabry-Perot resonant cavity principle | 南昌大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-114269718-A | Method for producing nitrogen-containing fluorine-containing compound | ＡＧＣ株式会社 | 2022-04-01 | — | — | CN | disclosed |
| CN-113983761-A | Helium extracting device and natural gas helium extracting method | 中石化石油工程技术服务有限公司 | 2022-01-28 | — | — | CN | disclosed |
| US-20150099800-A1 | NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF | NIH - DEITR | 2015-04-09 | — | — | US | disclosed |
| WO-2013177492-A2 | NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF | NORTHEASTERN UNIVERSITY (US) | 2013-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099800-A1 | NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF | PNLIP, LIPE, LIPC | F2 2200/4885ADRA2B 2207/4885ADRA2C 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.