Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 14/20 | 0.73 |
| ▸ | TYMP | P19971 | 2/20 | 0.69 |
| ▸ | CDC25B | P30305 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25418782 | 0.74 | GPR84 (0.54) | GPR84TYMP | |
| SCHEMBL4082607 | 0.74 | MAPT (0.68) | — | |
| SCHEMBL8154153 | 0.73 | GPR84 (0.53) | GPR84TYMP | |
| SCHEMBL21234494 | 0.72 | UNG (0.55) | GPR84TYMP | |
| SCHEMBL3299074 | 0.72 | HPGD (0.59) | GPR84TYMPCDC25B | |
| SCHEMBL22639826 | 0.72 | SMN1; SMN2 (0.74) | CDC25B | |
| SCHEMBL21667343 | 0.71 | MEN1 (0.61) | GPR84CDC25B | |
| SCHEMBL21667215 | 0.71 | SMN1; SMN2 (0.53) | GPR84CDC25B | |
| SCHEMBL21221785 | 0.70 | UNG (0.60) | GPR84 | |
| SCHEMBL1287276 | 0.70 | SMN1; SMN2 (0.69) | GPR84TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448256-B1 | PRECURSORS OF N-SUBSTITUTED DERIVATIVES OF 6-AMINOURACILS, 6-AMINOISOCYTOSINES, GUANINES AND 2-AMINOADENINES HAVING A CLEAVABLE ESTER GROUP; GREATER WATER SOLUBILITY AND ORAL BIOAVAILABILITY; TREATING GRAM POSITIVE BACTERIAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS | 2002-09-10 | — | — | US | disclosed |
| EP-1185517-A1 | ANTIBIOTIC PRODRUGS | University of Massachusetts (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071523-A1 | ANTIBIOTIC PRODRUGS | UNIVERSITY OF MASSACHUSETTS (US) | 2000-11-30 | — | — | WO | disclosed |
| EP-0772439-B1 | Novel antibiotic compounds and antibiotic compositions comprising said compounds for inhibiting gram positive bacteria and mycoplasma cells. | UNIV MASSACHUSETTS MEDICAL (US) | 2000-10-04 | — | — | EP | disclosed |