SCHEMBL8154153

SCHEMBL8154153

O=c1cc(NNc2ccccc2)[nH]c(=O)[nH]1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 5/20 0.53
MAPT P10636 1/20 0.53
HTT P42858 1/20 0.53
APAF1 O14727 1/20 0.51
KDM4C Q9H3R0 1/20 0.51
TYMP P19971 2/20 0.50
TAAR1 Q96RJ0 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4082607 0.83 MAPT (0.68) MAPTHTT
SCHEMBL7563397 0.73 GPR84 (0.73) GPR84TYMP
SCHEMBL3236991 0.72 GPR84 (0.49) GPR84MAPTHTT
SCHEMBL21221793 0.72 MAPT (0.61) GPR84MAPTHTT
SCHEMBL21221768 0.70 UNG (0.56) GPR84MAPTHTT
SCHEMBL21221877 0.69 MAPT (0.68) MAPTHTT
SCHEMBL5309210 0.68 APAF1 (0.56) GPR84MAPTHTTAPAF1
SCHEMBL21234494 0.67 UNG (0.55) GPR84TYMP
SCHEMBL9242561 0.67 GPR84 (0.52) GPR84MAPTHTTKDM4C
SCHEMBL8974784 0.67 GPR84 (0.50) GPR84KDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0772439-B1 Novel antibiotic compounds and antibiotic compositions comprising said compounds for inhibiting gram positive bacteria and mycoplasma cells. UNIV MASSACHUSETTS MEDICAL (US) 2000-10-04 EP disclosed