Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567727 | 0.78 | ALOX12 (0.60) | KMT2AMEN1SMN1; SMN2HIF1ANPC1 | |
| SCHEMBL4820844 | 0.71 | HIF1A (0.72) | KMT2AMEN1SMN1; SMN2HIF1ANPC1 | |
| SCHEMBL7563849 | 0.70 | POLB (0.51) | KMT2ASMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL8078072 | 0.69 | PPARA (0.53) | SMN1; SMN2LMNAFFAR4 | |
| SCHEMBL3697457 | 0.69 | LMNA (0.50) | SMN1; SMN2ALDH1A1LMNAFFAR4L3MBTL1 | |
| SCHEMBL15613891 | 0.68 | HSD17B10 (0.57) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL2553169 | 0.68 | KMT2A (0.63) | KMT2AMEN1SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL28134005 | 0.68 | ALDH1A1 (0.61) | KMT2AMEN1SMN1; SMN2HIF1ANPC1 | |
| SCHEMBL612449 | 0.68 | FFAR4 (0.51) | KMT2AMEN1HIF1AKDM4EALDH1A1 | |
| SCHEMBL7086937 | 0.67 | LMNA (0.51) | KMT2AMEN1ALDH1A1LMNAFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689845-B1 | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis | AMERICAN CYANAMID CO (US) | 2002-09-04 | — | — | EP | disclosed |
| US-5773001-A | ANTIGROWTH AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0689845-A2 | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis | AMERICAN CYANAMID COMPANY (US) | 1996-01-03 | — | — | EP | disclosed |