Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15809743 | 0.77 | NISCH (0.34) | NISCHCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL186905 | 0.74 | KDM4E (0.50) | METAP2MAPTCYP1A2HSP90AA1NPC1 | |
| SCHEMBL359859 | 0.73 | METAP2 (0.37) | NISCHCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL2372190 | 0.73 | HSP90AA1 (0.34) | CYP2D6MAPTHSP90AA1 | |
| SCHEMBL78566 | 0.68 | NISCH (0.50) | NISCHCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL29598957 | 0.68 | NISCH (0.50) | NISCHCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL29454745 | 0.68 | NISCH (0.50) | NISCHCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL9117411 | 0.68 | — | — | |
| SCHEMBL940051 | 0.67 | KDM4E (0.33) | — | |
| SCHEMBL317129 | 0.67 | GOT1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174520-A1 | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2023-06-08 | — | — | US | claimed |
| CN-108602777-B | 3- ((hetero-) aryl) -alkyl-8-amino-2-oxo-1, 3-aza-spiro- [4.5] -decane derivative | 格吕伦塔尔有限公司 | 2022-05-03 | — | — | CN | claimed |
| US-20210179592-A1 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2021-06-17 | — | — | US | claimed |
| EP-3652157-B1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2021-05-05 | — | — | EP | claimed |
| US-20200399252-A1 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2020-12-24 | — | — | US | claimed |
| US-10829480-B2 | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives | GRUENENTHAL GMBH (DE) | 2020-11-10 | — | — | US | claimed |
| US-20200331864-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2020-10-22 | — | — | US | claimed |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | Grünenthal GmbH (DE) | 2020-08-11 | — | — | US | claimed |
| EP-3652157-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2020-05-20 | — | — | EP | claimed |
| EP-3402784-B1 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-03-11 | — | — | EP | claimed |
| WO-2012078593-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | AMIRA PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | claimed |
| EP-1542678-B1 | 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE DERIVATIVES AS CANNABINOID-CB sb 1 /sb RECEPTOR LIGANDS | SOLVAY PHARM BV (NL) | 2010-02-24 | — | — | EP | claimed |
| EP-1438296-B1 | 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY | SOLVAY PHARM BV (NL) | 2008-11-26 | — | — | EP | claimed |
| EP-1758911-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-03-07 | — | — | EP | claimed |
| WO-2005111047-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | claimed |
| EP-1301490-A2 | 5-SUBSTITUTED 2-ARYL-4-PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2003-04-16 | — | — | EP | claimed |
| WO-2002006242-A2 | 5-SUBSTITUTED 2-ARYL-4-PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2002-01-24 | — | — | WO | claimed |
| CN-1071754-C | Pyrimidinylpyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2001-09-26 | — | — | CN | claimed |
| EP-0370629-B2 | Fungicides | ZENECA LTD (GB) | 1998-01-07 | — | — | EP | claimed |
| CN-1166833-A | pyrimidinyl pyrazole derivatives | DAIICHI SEIYAKU CO (JP) | 1997-12-03 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174520-A1 | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, ARRB1 | NISCH 1873/4885CYP2D6 94/4885CYP19A1 1080/4885 |
| US-20210179592-A1 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, ARRB1 | NISCH 1873/4885CYP2D6 94/4885CYP19A1 1080/4885 |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | OPRK1, OPRD1, OPRL1 | NISCH 1789/4885CYP2D6 292/4885CYP19A1 532/4885 |
| US-20200331864-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | NISCH 1789/4885CYP2D6 292/4885CYP19A1 532/4885 |
| US-20200399252-A1 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, ARRB1 | NISCH 1873/4885CYP2D6 94/4885CYP19A1 1080/4885 |
| US-10829480-B2 | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives | OPRD1, OPRK1, OPRL1 | NISCH 1831/4885CYP2D6 93/4885CYP19A1 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.