Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.50 |
| ▸ | RXRB | P28702 | 6/20 | 0.50 |
| ▸ | RXRG | P48443 | 6/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565539 | 0.91 | RXRA (0.42) | RXRARXRBRXRGCA12CA1 | |
| SCHEMBL8116217 | 0.89 | RXRA (0.39) | RXRARXRBRXRGCA12CA1 | |
| SCHEMBL8124508 | 0.85 | RXRA (0.68) | RXRARXRBRXRGALDH1A1RARA | |
| SCHEMBL8116657 | 0.83 | HPGD (0.43) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7563636 | 0.78 | RAB9A (0.52) | CA1CA2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6086410 | 0.76 | RXRA (0.48) | RXRARXRBRXRGCA12CA1 | |
| SCHEMBL7564506 | 0.76 | RXRA (0.46) | RXRARXRBRXRGCA12CA1 | |
| SCHEMBL8117130 | 0.75 | RXRA (0.45) | RXRARXRBRXRGCA12CA1 | |
| SCHEMBL8125521 | 0.75 | RXRA (0.55) | RXRARXRBRXRGCA12CA2 | |
| SCHEMBL6087437 | 0.74 | RXRA (0.47) | RXRARXRBRXRGCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228055-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012618-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6093838-A | FOR TREATING SKIN-RELATED DISEASES, INCLUDING ACTINIC KERATOSES, ARSENIC KERATOSES, ECZEMA | ALLERGAN SALES, INC. (US) | 2000-07-25 | — | — | US | disclosed |