Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | HSF1 | Q00613 | 3/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202844 | 0.83 | PDE2A (0.35) | NR1H3TRPM8PDE2APDE10AALDH1A1 | |
| SCHEMBL7471708 | 0.75 | NR1H2 (0.38) | NR1H3TRPM8MAPTCRHR1SMN1; SMN2 | |
| SCHEMBL7526323 | 0.73 | PDE2A (0.34) | NR1H3TRPM8PDE2APDE10ASMN1; SMN2 | |
| SCHEMBL7532307 | 0.72 | PDE2A (0.33) | NR1H3TRPM8PDE2APDE10AALDH1A1 | |
| SCHEMBL5726642 | 0.70 | PDE2A (0.33) | NR1H3TRPM8PDE2APDE10AMAPT | |
| SCHEMBL9577157 | 0.69 | HSD11B1 (0.46) | NR1H3PDE2APDE10ACRHR1KMT2A | |
| SCHEMBL7522944 | 0.68 | KDM4E (0.32) | PDE2APDE10AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7527087 | 0.68 | PDE2A (0.35) | NR1H3PDE2APDE10AALDH1A1MAPT | |
| SCHEMBL6209661 | 0.68 | PDE2A (0.37) | NR1H3PDE2APDE10AALDH1A1MAPT | |
| SCHEMBL9026017 | 0.67 | HSD11B1 (0.49) | NR1H3ALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417187-B2 | PALLADIUM CATALYZED ARYLATION, ALKYLATION, DEIODINATION OR DEBROMINATION | DOW AGROSCIENCES LLC | 2002-07-09 | — | — | US | disclosed |
| US-20020019370-A1 | Palladium catalyzed arylation, alkylation, deiodination or debromination | DOW AGROSCIENCES LLC | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019370-A1 | Palladium catalyzed arylation, alkylation, deiodination or debromination | DDT, TYR, DDC | NR1H3 3235/4885HSF1 4624/4885ESR1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.