SCHEMBL7565024

SCHEMBL7565024

C=CCN1C=CC(c2nc(-c3ccc(C(=O)N[C@@H](CC(C)C)C(=O)N(C)C#N)cc3)cs2)=CC1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CTSB P07858 8/20 0.41
CTSK P43235 12/20 0.39
CTSS P25774 8/20 0.39
CTSL P07711 6/20 0.39
NPC1 O15118 2/20 0.38
MAPT P10636 2/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 1/20 0.38
HPGD P15428 1/20 0.38
CAPN1 P07384 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7486617 0.89 CTSB (0.45) CTSBCTSKCTSSCTSLNPC1
SCHEMBL7043084 0.88 CTSK (0.49) CTSBCTSKCTSSCTSLNPC1
SCHEMBL7569982 0.81 CTSB (0.44) CTSBCTSKCTSSCTSLNPC1
SCHEMBL7539652 0.79 CTSB (0.41) CTSBCTSKCTSSCTSLNPC1
SCHEMBL7515230 0.78 CTSB (0.52) CTSBCTSKCTSSCTSLNPC1
SCHEMBL7540238 0.77 CTSK (0.58) CTSBCTSKCTSSCTSLNPC1
SCHEMBL7539033 0.77 CTSB (0.44) CTSBCTSKCTSSCTSLKDM4E
SCHEMBL7450076 0.76 CTSB (0.54) CTSBCTSKCTSSCTSLNPC1
SCHEMBL6185994 0.76 CTSB (0.54) CTSBCTSKCTSSCTSLNPC1
SCHEMBL7450318 0.76 CTSB (0.54) CTSBCTSKCTSSCTSLKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001068645-A2 N-CYANOMETHYLCARBOXAMIDES AND THEIR USE AS PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2001-09-20 WO claimed
WO-2001068645-A2 N-CYANOMETHYLCARBOXAMIDES AND THEIR USE AS PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2001-09-20 WO disclosed