Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828560 | 0.88 | GPBAR1 (0.40) | HDAC4GPBAR1ARSMN1; SMN2SERPINE1 | |
| SCHEMBL7828963 | 0.87 | MAPT (0.38) | HDAC4MCHR1ALDH1A1MAPTMLYCD | |
| SCHEMBL7593043 | 0.83 | HDAC4 (0.42) | HDAC4GPBAR1ALDH1A1MAPTTLR7 | |
| SCHEMBL14376042 | 0.83 | HDAC4 (0.65) | HDAC4GPBAR1MCHR1TLR7L3MBTL1 | |
| SCHEMBL7562731 | 0.78 | HDAC4 (0.50) | HDAC4GPBAR1MCHR1ALDH1A1MAPT | |
| SCHEMBL7558781 | 0.77 | MAPT (0.40) | GPBAR1MAPTKDM5A | |
| SCHEMBL7559768 | 0.77 | MAPT (0.48) | GPBAR1MAPT | |
| SCHEMBL7564002 | 0.76 | HSP90AA1 (0.40) | HDAC4GPBAR1ALDH1A1MAPT | |
| SCHEMBL7565085 | 0.76 | KDM4E (0.40) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11983213 | 0.76 | L3MBTL1 (0.53) | HDAC4GPBAR1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511732-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | Active Biotech AB (SE) | 2005-03-09 | — | — | EP | claimed |
| WO-2003106424-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | ACTIVE BIOTECH AB (SE) | 2003-12-24 | — | — | WO | claimed |
| EP-1095021-A1 | QUINOLINE DERIVATIVES | Active Biotech AB (SE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000003991-A1 | QUINOLINE DERIVATIVES | ACTIVE BIOTECH AB (SE) | 2000-01-27 | — | — | WO | claimed |
| EP-1511732-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | Active Biotech AB (SE) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003106424-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | ACTIVE BIOTECH AB (SE) | 2003-12-24 | — | — | WO | disclosed |
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | disclosed |