Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567651 | 0.76 | ADORA3 (0.44) | RAB9ANPC1ALDH1A1MAPTMEN1 | |
| SCHEMBL27473744 | 0.74 | ANO1 (0.56) | ANO1RAB9ANPC1ALDH1A1PSMD14 | |
| SCHEMBL4086973 | 0.73 | JAK2 (0.72) | MEN1KMT2AHDAC6IKBKB | |
| SCHEMBL7936378 | 0.71 | GPR35 (0.52) | ANO1RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL6758522 | 0.71 | HDAC6 (0.58) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL2141492 | 0.71 | IRAK4 (0.66) | RAB9ANPC1MAPTHDAC6IRAK4 | |
| SCHEMBL2368666 | 0.70 | RAB9A (0.55) | RAB9AALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5556395 | 0.69 | JAK2 (0.63) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL1898701 | 0.69 | ANO1 (0.80) | ANO1RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL10918258 | 0.68 | MKNK1 (0.53) | ALDH1A1MKNK1MKNK2HDAC6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261600-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | AstraZeneca AB (SE) | 2002-12-04 | — | — | EP | claimed |
| WO-2001058890-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | claimed |