Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | KMO | O15229 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196570 | 0.84 | ALDH1A1 (0.62) | ALDH1A1HPGDMEN1LMNAKMT2A | |
| SCHEMBL1799330 | 0.84 | KMT2A (0.69) | ALDH1A1HPGDMEN1LMNAKMT2A | |
| SCHEMBL8188234 | 0.81 | KMT2A (0.65) | ALDH1A1HPGDMEN1LMNAKMT2A | |
| SCHEMBL689937 | 0.80 | ALDH1A1 (0.77) | ALDH1A1HPGDMEN1LMNAKMT2A | |
| SCHEMBL27473744 | 0.78 | ANO1 (0.56) | GPR35ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL27749754 | 0.76 | HSD17B10 (0.63) | GPR35ALDH1A1HPGDMEN1LMNA | |
| SCHEMBL13838083 | 0.76 | PRKCZ (0.61) | ALDH1A1HPGDMEN1LMNAKMT2A | |
| SCHEMBL28675027 | 0.75 | KMO (0.51) | GPR35ALDH1A1MEN1KMT2AMKNK1 | |
| SCHEMBL4932598 | 0.75 | HSD17B10 (0.51) | ALDH1A1HPGDMEN1LMNAKMT2A | |
| SCHEMBL12465745 | 0.75 | HSD17B10 (0.51) | ALDH1A1HPGDMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| CN-101351453-A | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2009-01-21 | — | — | CN | disclosed |
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |