Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | HPGD | P15428 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564694 | 0.88 | NPC1 (0.35) | NPC1RAB9APOLB | |
| SCHEMBL7568491 | 0.87 | NPC1 (0.37) | NPC1RAB9ALMNAKDM4EHPGD | |
| SCHEMBL9468018 | 0.84 | NPC1 (0.46) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL75918 | 0.82 | NPC1 (0.46) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL4444920 | 0.81 | NPC1 (0.46) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL21802375 | 0.81 | NPC1 (0.43) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL20363907 | 0.80 | NPC1 (0.47) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL27503342 | 0.80 | RAB9A (0.57) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL30112936 | 0.80 | KDM4E (0.46) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL342550 | 0.80 | KDM4E (0.46) | NPC1RAB9ALMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855393-B1 | BISBENZOTRIAZOLYLPHENOLS | OTSUKA KAGAKU KK (JP) | 2002-08-14 | — | — | EP | claimed |