Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566388 | 0.91 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL27486507 | 0.82 | GRIA1 (0.34) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL27436503 | 0.80 | GRIA1 (0.33) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL7565564 | 0.76 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8660079 | 0.74 | ALDH1A1 (0.39) | ALDH1A1MAPTNPSR1LMNAKDM4E | |
| SCHEMBL8660076 | 0.72 | ALDH1A1 (0.39) | ALDH1A1MAPTNPSR1LMNAKDM4E | |
| SCHEMBL25347587 | 0.69 | MAPT (0.51) | ALDH1A1MAPTNPSR1L3MBTL1LMNA | |
| SCHEMBL7567175 | 0.68 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL27459486 | 0.65 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL27433911 | 0.65 | GRIA1 (0.36) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1125818-C | Amino acid derivatives of substituted quinoxaline 2, 3 -dione derivativesa as glutamate receptor antagonists | WARNER LAMBERT CO (US) | 2003-10-29 | — | — | CN | disclosed |
| EP-0832074-B1 | AMINO ACID DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2002-09-04 | — | — | EP | disclosed |
| CN-1187190-A | Amino acid derivatives of substituted quinoxaline 2, 3-dione derivatives as glutamate receptor antagonists | WARNER LAMBERT CO (US) | 1998-07-08 | — | — | CN | disclosed |
| US-5614508-A | ANTIISCHEMIC AGENTS, ALZHEIMERS, STROKE OR NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996040649-A1 | AMINO ACID DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-12-19 | — | — | WO | disclosed |