Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL28672604 | 0.82 | MEN1 (0.50) | MEN1LMNAKMT2ACA2 | |
| Methylamine SCHEMBL2157105 | 0.77 | — | — | |
| SCHEMBL130487 | 0.76 | — | — | |
| Tromethamine SCHEMBL11143695 | 0.74 | MEN1 (0.59) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL1508805 | 0.74 | LMNA (0.67) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL5988271 | 0.74 | LMNA (0.67) | MEN1LMNAKMT2ACA2 | |
| Ammonia Solution, Strong SCHEMBL7734950 | 0.74 | — | — | |
| Tromethamine SCHEMBL4939766 | 0.74 | LMNA (0.67) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL6064575 | 0.72 | LMNA (0.56) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL7567312 | 0.72 | MEN1 (0.34) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002081487-A1 | LOW CONCENTRATION RATES | PT. MITRA CHEMINDO SEJATI (ID) | 2002-10-17 | — | — | WO | claimed |
| WO-2002081487-A1 | LOW CONCENTRATION RATES | PT. MITRA CHEMINDO SEJATI (ID) | 2002-10-17 | — | — | WO | disclosed |