Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NT5E | P21589 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11143695 | 0.86 | MEN1 (0.59) | LMNAMEN1KMT2ACA1CA2 | |
| Tromethamine SCHEMBL28419666 | 0.85 | LMNA (0.46) | LMNAMEN1KMT2ASLC6A6CYP2C19 | |
| Tromethamine SCHEMBL5988271 | 0.85 | LMNA (0.67) | LMNAMEN1KMT2ASLC6A6CYP2C19 | |
| Tromethamine SCHEMBL1508805 | 0.85 | LMNA (0.67) | LMNAMEN1KMT2ASLC6A6CYP2C19 | |
| Tromethamine SCHEMBL4939766 | 0.85 | LMNA (0.67) | LMNAMEN1KMT2ASLC6A6CYP2C19 | |
| Tromethamine SCHEMBL11647748 | 0.79 | MEN1 (0.67) | LMNAMEN1KMT2ATNNC1SGPL1 | |
| Tromethamine SCHEMBL28672604 | 0.79 | MEN1 (0.50) | LMNAMEN1KMT2ACA1CA2 | |
| SCHEMBL5454990 | 0.79 | LMNA (0.38) | LMNAMEN1KMT2ASLC6A6CYP2C19 | |
| Tromethamine SCHEMBL571834 | 0.78 | MEN1 (0.77) | LMNAMEN1KMT2ATNNC1SGPL1 | |
| Tromethamine SCHEMBL1019777 | 0.78 | MEN1 (0.77) | LMNAMEN1KMT2ATNNC1SGPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118079674-A | Selective nanofiltration membrane and preparation method and application thereof | 中国科学院过程工程研究所 | 2024-05-28 | — | — | CN | disclosed |
| EP-1692291-A2 | SYSTEM FOR THE INDUCIBLE EXPRESSION OF RECOMBINANT PROTEINS IN CYANOBACTERIA | UNIVERSITE LOUIS PASTEUR (FR) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005052168-A2 | SYSTEM FOR THE INDUCIBLE EXPRESSION OF RECOMBINANT PROTEINS IN CYANOBACTERIA | UNIVERSITE LOUIS PASTEUR (FR) | 2005-06-09 | — | — | WO | disclosed |
| EP-0620282-B1 | Method of extracting, amplifying and detecting a nucleic acid from whole blood | JOHNSON & JOHNSON CLIN DIAG (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5429726-A | Using polyethylenimine formaldehyde scavengers and measurement with polarography | THE YELLOW SPRINGS INSTRUMENT COMPANY, INC. (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0620282-A1 | Method of extracting, amplifying and detecting a nucleic acid from whole blood | CLINICAL DIAGNOSTIC SYSTEMS, INC. (US) | 1994-10-19 | — | — | EP | disclosed |
| US-5334499-A | Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction | EASTMAN KODAK COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0393744-A1 | Methods of extracting, amplifying and detecting a nucleic acid from PBMC blood fraction | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1990-10-24 | — | — | EP | disclosed |
| US-4368287-A | POLYESTER CONTAINING AMINO-SULFONIC AMPHOIONIC GROUP | NIPPON PAINT CO., LTD. (JP) | 1983-01-11 | — | — | US | disclosed |
| US-4328143-A | Aqueous coating composition | NIPPON PAINT COMPANY, LTD. (JP) | 1982-05-04 | — | — | US | disclosed |
| US-4322324-A | Ampho-ionic group-containing alkyd resins | NIPPON PAINT CO., LTD. (JP) | 1982-03-30 | — | — | US | disclosed |