⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567431 | 0.80 | NLRP3 (0.62) | — | |
| SCHEMBL9504118 | 0.80 | LMNA (0.58) | — | |
| SCHEMBL7082105 | 0.80 | NLRP3 (0.50) | — | |
| SCHEMBL7573234 | 0.79 | NLRP3 (0.54) | — | |
| SCHEMBL8962577 | 0.78 | TSHR (0.46) | — | |
| SCHEMBL9386678 | 0.77 | NLRP3 (0.47) | — | |
| SCHEMBL9723518 | 0.77 | LMNA (0.54) | — | |
| SCHEMBL7080985 | 0.75 | — | — | |
| SCHEMBL7104643 | 0.74 | — | — | |
| SCHEMBL8984942 | 0.73 | NLRP3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183384-A1 | Methods of treating nuclear factor-kappa B mediated diseases and disorders | CORNICELLI JOSEPH ANTHONY (US) | 2002-12-05 | — | — | US | claimed |
| EP-1236468-A1 | Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| EP-0556322-B1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER LAMBERT CO (US) | 1996-06-12 | — | — | EP | claimed |
| US-5288757-A | Aminosulfonyl urea ACAT inhibitors and a method of lowering blood cholesterol levels therewith | WARNER-LAMBERT COMPANY (US) | 1994-02-22 | — | — | US | claimed |
| EP-0556322-A1 | AMINOSULFONYL UREA ACAT INHIBITORS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | claimed |
| WO-1992008694-A1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1992-05-29 | — | — | WO | claimed |
| US-20020183384-A1 | Methods of treating nuclear factor-kappa B mediated diseases and disorders | CORNICELLI JOSEPH ANTHONY (US) | 2002-12-05 | — | — | US | disclosed |
| EP-1236468-A1 | Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-0556322-B1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER LAMBERT CO (US) | 1996-06-12 | — | — | EP | disclosed |
| US-5288757-A | Aminosulfonyl urea ACAT inhibitors and a method of lowering blood cholesterol levels therewith | WARNER-LAMBERT COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| US-5214206-A | Anticholesterol agents, inhibitors of acylcoenzyme A | WARNER-LAMBERT COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| WO-1992008694-A1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |