Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9723518 | 0.93 | LMNA (0.54) | LMNAKMT2ALPAR1 | |
| SCHEMBL9844414 | 0.84 | SOAT1 (0.58) | LMNAKMT2A | |
| SCHEMBL9848451 | 0.81 | LMNA (0.51) | LMNAKMT2ALPAR1 | |
| SCHEMBL462304 | 0.81 | LPAR1 (0.66) | LMNAKMT2ALPAR1 | |
| SCHEMBL7573234 | 0.80 | NLRP3 (0.54) | — | |
| SCHEMBL7567348 | 0.80 | — | — | |
| SCHEMBL9844254 | 0.80 | SOAT1 (0.55) | KMT2A | |
| SCHEMBL9504026 | 0.80 | SOAT2 (0.57) | — | |
| SCHEMBL8321568 | 0.79 | — | — | |
| SCHEMBL9678841 | 0.79 | KMT2A (0.55) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335374-B1 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1993-06-30 | — | — | EP | claimed |
| US-5116848-A | N-(((2,6-DISUBSTITUTED)PHENYL)-N-DIARYLALKYL)UREAS AS ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-26 | — | — | US | claimed |
| EP-0335374-B1 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1993-06-30 | — | — | EP | disclosed |
| US-5116848-A | N-(((2,6-DISUBSTITUTED)PHENYL)-N-DIARYLALKYL)UREAS AS ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0335374-A2 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |