SCHEMBL7568030

SCHEMBL7568030

Cc1cc(C(=O)C=O)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 1/20 0.47
TAS1R1 Q7RTX1 1/20 0.47
TAS1R2 Q8TE23 1/20 0.47
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
ALDH1A1 P00352 3/20 0.42
MAPK1 P28482 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
TSHR P16473 2/20 0.41
MAPT P10636 3/20 0.41
NPC1 O15118 1/20 0.41
POLB P06746 1/20 0.41
RAB9A P51151 1/20 0.41
MCL1 Q07820 1/20 0.41
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
DPP4 P27487 1/20 0.40
GPR183 P32249 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL11074038 0.98 TAS1R3 (0.46) TAS1R3TAS1R1TAS1R2CYP1A2CYP3A4
Water SCHEMBL11073909 0.83 HPGD (0.47) CYP3A4ALDH1A1MAPK1TDP1MAPT
SCHEMBL12647578 0.83 CYP3A4 (0.49) TAS1R3TAS1R1TAS1R2CYP1A2CYP3A4
SCHEMBL1483722 0.82 SMN1; SMN2 (0.52) TAS1R3TAS1R1ALDH1A1MAPK1TDP1
SCHEMBL1484306 0.82 TSHR (0.59) ALDH1A1MAPK1TDP1TSHRMAPT
Water SCHEMBL11291160 0.80 TSHR (0.57) ALDH1A1MAPK1TDP1TSHRMAPT
SCHEMBL10845040 0.80 TSHR (0.57) ALDH1A1MAPK1TDP1TSHRMAPT
SCHEMBL4352652 0.79 HTT (0.53) TAS1R3TAS1R1TAS1R2CYP1A2CYP3A4
SCHEMBL9448915 0.79 ALDH1A1 (0.51) TAS1R3TAS1R1TAS1R2CYP1A2CYP3A4
SCHEMBL10554190 0.79 GRM2 (0.41) CYP1A2CYP2C19ALDH1A1MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002085369-A1 INHIBITORS OF ANTHRAX LETHAL FACTOR ACTIVITY STRUCTURAL BIOINFORMATICS, INC. (US) 2002-10-31 WO disclosed
US-6436933-B1 1-HYDROXY-3-(2-METHYLPROPYL)-5,6-DIPHENYLHYDROPYRAZIN-2-ONE STRUCTURAL BIOINFORMATICS INC. 2002-08-20 US disclosed