Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7171129 | 1.00 | GPR52 (0.51) | GPR52HDAC8HDAC6PARP1ALDH1A1 | |
| SCHEMBL31167604 | 0.88 | GPR52 (0.61) | GPR52HDAC8HDAC6PARP1ALDH1A1 | |
| SCHEMBL10546316 | 0.85 | KCNK3 (0.51) | GPR52HDAC8HDAC6PARP1MEN1 | |
| SCHEMBL29098722 | 0.84 | MAPT (0.54) | GPR52HDAC8HDAC6PARP1ALDH1A1 | |
| Dimethyl Maleate SCHEMBL7515581 | 0.84 | SMN1; SMN2 (0.49) | GPR52HDAC8HDAC6PARP1ALDH1A1 | |
| SCHEMBL7102918 | 0.81 | ALDH1A1 (0.62) | GPR52HDAC8HDAC6PARP1ALDH1A1 | |
| SCHEMBL7102919 | 0.81 | ALDH1A1 (0.62) | GPR52HDAC8HDAC6PARP1ALDH1A1 | |
| SCHEMBL3031262 | 0.80 | AKT1 (0.58) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3031264 | 0.80 | AKT1 (0.58) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6519835 | 0.80 | CTNNB1 (0.48) | HDAC8HDAC6PARP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259491-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | Abbott Laboratories (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001060802-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES, AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-08-23 | — | — | WO | disclosed |