Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.45 |
| ▸ | EDNRB | P24530 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568861 | 0.84 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL7575836 | 0.76 | KDM4E (0.33) | ALDH1A1 | |
| SCHEMBL7567984 | 0.76 | L3MBTL1 (0.44) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8441879 | 0.75 | FABP4 (0.34) | EDNRAEDNRBALDH1A1LMNA | |
| SCHEMBL7568989 | 0.74 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8522668 | 0.72 | ITGB1 (0.33) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7565743 | 0.72 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL8441932 | 0.70 | EDNRA (0.45) | EDNRAEDNRB | |
| SCHEMBL7814508 | 0.70 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL1040233 | 0.70 | UQCRB (0.65) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6133442-A | FOR THE TREATMENT OF DISORDERS WHICH ARE ASSOCIATED WITH ENDOTHELIN ACTIVITIES, ESPECIALLY CIRCULATORY DISORDERS SUCH AS HYPERTENSION, ISCHAEMIA, VASOSPASMS AND ANGINA PECTORIS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-17 | — | — | US | disclosed |