Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27789171 | 0.79 | NPC1 (0.48) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL899534 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL2658364 | 0.74 | ALDH1A1 (0.47) | SMN1; SMN2LMNAMEN1KMT2ACASP3 | |
| SCHEMBL16217142 | 0.74 | RAB9A (0.52) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL26686536 | 0.71 | MAPT (0.49) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL27791948 | 0.71 | NPC1 (0.50) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL2066324 | 0.71 | FFAR2 (0.40) | SMN1; SMN2MAPTKDM4ERAB9AALDH1A1 | |
| SCHEMBL11472883 | 0.70 | LTA4H (0.47) | SMN1; SMN2MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL2066400 | 0.69 | MEN1 (0.56) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL10253385 | 0.69 | MAPT (0.44) | SMN1; SMN2LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218376-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-1218376-A1 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001017995-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |