Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795814 | 0.82 | ALDH1A1 (0.46) | HPGDLMNACYP1A2ALDH1A1KDM4E | |
| SCHEMBL12862551 | 0.81 | SMN1; SMN2 (0.45) | HPGDLMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9540156 | 0.79 | POLB (0.45) | RECQLHPGDLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL11868257 | 0.78 | HDAC1 (0.37) | ADRB1ADRB3 | |
| SCHEMBL10619078 | 0.78 | GSK3A (0.44) | RECQLHPGDLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL15478286 | 0.77 | KDM4E (0.41) | KMOADRB1ADRB3HPGDSMN1; SMN2 | |
| SCHEMBL29093825 | 0.77 | ALDH1A1 (0.35) | KMOADRB1ADRB3HPGDLMNA | |
| SCHEMBL11127625 | 0.77 | ADRB1 (0.35) | RECQLKMOADRB1ADRB3HPGD | |
| SCHEMBL10621833 | 0.76 | KMO (0.57) | KMOLMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3672244 | 0.76 | PLK1 (0.41) | RECQLKMOADRB1ADRB3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966476-B1 | Quinazolinone compounds | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| US-6156739-A | Quinazolinone compounds | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |
| EP-0966476-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998033802-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-08-06 | — | — | WO | disclosed |