Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29981747 | 1.00 | CYP1A2 (0.46) | CYP1A2CYP2D6GPR84CHRNA7CYP19A1 | |
| SCHEMBL9807642 | 0.86 | CYP19A1 (0.54) | CYP1A2CYP2D6CYP19A1HRH4HRH3 | |
| SCHEMBL4814640 | 0.76 | FLT1 (0.48) | CYP1A2CYP2D6GPR84CHRNA7CYP2A6 | |
| SCHEMBL7074857 | 0.74 | MPO (0.44) | CYP1A2CYP2D6CYP19A1TDP1KDM4E | |
| SCHEMBL7551411 | 0.74 | LMNA (0.42) | CYP1A2CYP2D6CYP19A1TDP1KDM4E | |
| SCHEMBL5270596 | 0.74 | EGFR (0.46) | CYP1A2CYP2D6CYP19A1TDP1KDM4E | |
| SCHEMBL29485692 | 0.74 | CHRNA7 (0.74) | CYP1A2CYP2D6CHRNA7CYP2A6HRH4 | |
| SCHEMBL724866 | 0.74 | CHRNA7 (0.74) | CYP1A2CYP2D6CHRNA7CYP2A6HRH4 | |
| SCHEMBL31738482 | 0.74 | CYP19A1 (0.61) | CYP1A2CYP2D6CYP19A1TDP1KDM4E | |
| SCHEMBL7069713 | 0.74 | CYP19A1 (0.61) | CYP1A2CYP2D6CYP19A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165085-A1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | Novartis AG (CH) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059509-A1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2000-10-12 | — | — | WO | disclosed |