Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029235 | 0.88 | ALOX5 (0.44) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5713090 | 0.88 | PPARA (0.44) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5713084 | 0.86 | MAPT (0.40) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7576875 | 0.86 | ALOX5 (0.41) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2032129 | 0.81 | ALOX5 (0.44) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2029297 | 0.79 | PDE7A (0.46) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7493616 | 0.77 | ALOX5 (0.41) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2030702 | 0.72 | ILK (0.44) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5713076 | 0.72 | SMN1; SMN2 (0.46) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2008073 | 0.72 | AKR1B1 (0.45) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192137-A1 | COMPOUNDS FOR THE MODULATION OF PPAR$g(g) ACTIVITY | Tularik Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001000579-A1 | COMPOUNDS FOR THE MODULATION OF PPARη ACTIVITY | TULARIK INC. (US) | 2001-01-04 | — | — | WO | disclosed |