Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 7/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | GLB1 | P16278 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576875 | 0.86 | ALOX5 (0.41) | SMN1; SMN2NPSR1ALOX5PPARAKMT2A | |
| SCHEMBL5713090 | 0.84 | PPARA (0.44) | SMN1; SMN2NPSR1ALOX5PPARAGLB1 | |
| SCHEMBL12585006 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2NPSR1ALOX5PPARALOXL2 | |
| SCHEMBL2034875 | 0.78 | PPARA (0.49) | SMN1; SMN2NPSR1ALOX5PPARAGLB1 | |
| SCHEMBL12584997 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2NPSR1ALOX5PPARALOXL2 | |
| SCHEMBL5713084 | 0.74 | MAPT (0.40) | SMN1; SMN2NPSR1PPARAKMT2AALDH1A1 | |
| SCHEMBL7569633 | 0.72 | MAPT (0.40) | SMN1; SMN2NPSR1ALOX5PPARAKMT2A | |
| SCHEMBL8564013 | 0.72 | SMN1; SMN2 (0.59) | SMN1; SMN2NPSR1ALOX5PPARALOXL2 | |
| SCHEMBL12584982 | 0.71 | MAPT (0.45) | SMN1; SMN2NPSR1ALOX5PPARAGLB1 | |
| SCHEMBL2030702 | 0.71 | ILK (0.44) | SMN1; SMN2NPSR1ALOX5PPARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1722789-A2 | THERAPEUTIC MODULATION OF PPAR (GAMMA) ACTIVITY | Amgen Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005086904-A2 | THERAPEUTIC MODULATION OF PPAR (GAMMA) ACTIVITY | AMGEN INC. (US) | 2005-09-22 | — | — | WO | disclosed |
| EP-1192137-A1 | COMPOUNDS FOR THE MODULATION OF PPAR$g(g) ACTIVITY | Tularik Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001000579-A1 | COMPOUNDS FOR THE MODULATION OF PPARη ACTIVITY | TULARIK INC. (US) | 2001-01-04 | — | — | WO | disclosed |