Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ILK | Q13418 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2030702 | 0.87 | ILK (0.44) | ALOX5ILKDYRK1AAGPAT2L3MBTL1 | |
| SCHEMBL5713076 | 0.86 | SMN1; SMN2 (0.46) | ALOX5PPARAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7569633 | 0.86 | MAPT (0.40) | ALOX5DYRK1AAGPAT2L3MBTL1PPARA | |
| SCHEMBL2031349 | 0.80 | DYRK1A (0.46) | ALOX5ILKDYRK1AAGPAT2PPARA | |
| SCHEMBL2035992 | 0.76 | ILK (0.42) | ALOX5ILKDYRK1AAGPAT2L3MBTL1 | |
| SCHEMBL2029235 | 0.74 | ALOX5 (0.44) | ALOX5DYRK1AAGPAT2L3MBTL1PPARA | |
| SCHEMBL5713090 | 0.72 | PPARA (0.44) | ALOX5PPARAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5713084 | 0.71 | MAPT (0.40) | PPARAMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL2000138 | 0.69 | AKR1B1 (0.46) | ILKDYRK1AAKR1B1AKR1A1EPHX2 | |
| SCHEMBL2036572 | 0.69 | CYP3A4 (0.49) | ALOX5DYRK1AAGPAT2PPARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192137-A1 | COMPOUNDS FOR THE MODULATION OF PPAR$g(g) ACTIVITY | Tularik Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001000579-A1 | COMPOUNDS FOR THE MODULATION OF PPARη ACTIVITY | TULARIK INC. (US) | 2001-01-04 | — | — | WO | disclosed |