SCHEMBL7569714

SCHEMBL7569714

Nc1cccc(-c2nc(CS(=O)(=O)CCO)no2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
NPC1 O15118 4/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
RAB9A P51151 3/20 0.45
NOTUM Q6P988 2/20 0.43
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
LMNA P02545 1/20 0.41
POLB P06746 1/20 0.41
KDM4E B2RXH2 3/20 0.39
GAA P10253 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
HDAC1 Q13547 3/20 0.38
HDAC6 Q9UBN7 3/20 0.38
HDAC4 P56524 1/20 0.38
HDAC8 Q9BY41 3/20 0.37
MECP2 P51608 1/20 0.37
CA9 Q16790 3/20 0.36
CA12 O43570 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8404853 0.85 MEN1 (0.47) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM
SCHEMBL7564976 0.81 ALDH1A1 (0.61) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM
SCHEMBL22347233 0.74 NPC1 (0.50) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM
SCHEMBL8230862 0.74 NOTUM (0.45) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM
SCHEMBL8271604 0.74 ALDH1A1 (0.46) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM
SCHEMBL8399931 0.73 NPC1 (0.48) ALDH1A1NPC1RAB9ANOTUMKMT2A
SCHEMBL22347945 0.71 NR1H4 (0.45) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM
SCHEMBL11361627 0.70 ALDH1A1 (0.54) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM
SCHEMBL3001729 0.70 MAOA (0.43) ALDH1A1KMT2ALMNACA9CA12
SCHEMBL1272321 0.67 NOTUM (0.58) ALDH1A1NPC1SMN1; SMN2RAB9ANOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929610-B1 REACTIVE DYES WITH A HETEROCYCLIC ANCHOR DYSTAR TEXTILFARBEN GMBH & CO (DE) 2002-08-28 EP disclosed
US-6197941-B1 TRIAZINE, METALLIZED, AZO, ANTHRAQUINONE, FORMAZAN, PHTHALOCYANINE, AND DIOXAZINE DYES BASF AKTIENGESELLSCHAFT (DE) 2001-03-06 US disclosed
EP-0842163-B1 BENZENE DERIVATIVES WITH A HETEROCYCLIC GROUP BASF AG (DE) 1999-11-03 EP disclosed
EP-0929610-A1 REACTIVE DYES WITH A HETEROCYCLIC ANCHOR BASF AKTIENGESELLSCHAFT (DE) 1999-07-21 EP disclosed
US-5886187-A Benzene derivatives having a heterocyclic radical BASF AKTIENGESELLSCHAFT (DE) 1999-03-23 US disclosed
EP-0842163-A1 BENZENE DERIVATIVES WITH A HETEROCYCLIC GROUP BASF AKTIENGESELLSCHAFT (DE) 1998-05-20 EP disclosed
WO-1998014522-A1 REACTIVE DYES WITH A HETEROCYCLIC ANCHOR BASF AKTIENGESELLSCHAFT (DE) 1998-04-09 WO disclosed
WO-1997005124-A1 BENZENE DERIVATIVES WITH A HETEROCYCLIC GROUP BASF AKTIENGESELLSCHAFT (DE) 1997-02-13 WO disclosed