Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.92 |
| ▸ | GAA | P10253 | 1/20 | 0.92 |
| ▸ | HCAR3 | P49019 | 10/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10540328 | 0.90 | MAPT (0.83) | MAPTGAAHCAR3ALDH1A1TDP1 | |
| SCHEMBL11839922 | 0.82 | MAPT (0.75) | MAPTGAAHCAR3ALDH1A1TDP1 | |
| SCHEMBL6044024 | 0.82 | HCAR3 (1.00) | MAPTGAAHCAR3ALDH1A1 | |
| SCHEMBL22118775 | 0.82 | MAPT (0.71) | MAPTGAAHCAR3ALDH1A1TDP1 | |
| SCHEMBL11208444 | 0.81 | HCAR3 (0.97) | MAPTGAAHCAR3ALDH1A1 | |
| SCHEMBL6044600 | 0.81 | HCAR3 (0.97) | MAPTGAAHCAR3ALDH1A1 | |
| SCHEMBL11242963 | 0.81 | HCAR3 (0.97) | MAPTGAAHCAR3ALDH1A1 | |
| SCHEMBL11576924 | 0.81 | MAPT (0.88) | MAPTGAAHCAR3ALDH1A1TDP1 | |
| SCHEMBL13043456 | 0.79 | MAPT (0.68) | MAPTGAAHCAR3ALDH1A1TDP1 | |
| SCHEMBL6544560 | 0.78 | MAPT (0.64) | MAPTGAAHCAR3ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0685470-B1 | Benzene derivatives and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 2002-09-11 | — | — | EP | disclosed |
| US-5739131-A | TREATMENT OF KIDNEY DISORDERS; COMPOUNDS DO NOT AFFECT BLOOD PRESSURE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| US-5731310-A | KIDNEY DISEASE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-03-24 | — | — | US | disclosed |
| US-5696118-A | ADMINISTERING FOR TREATING KIDNEY DISEASE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-12-09 | — | — | US | disclosed |
| EP-0685470-A2 | Benzene derivatives and pharmaceutical composition | Kureha Chemical Industry Co., Ltd. (JP) | 1995-12-06 | — | — | EP | disclosed |