Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MTR | Q99707 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216661 | 0.91 | MTTP (0.56) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL7565332 | 0.90 | HTR7 (0.42) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL7570480 | 0.90 | SLC6A12 (0.48) | UBE2MDCUN1D1CCR3HTR7 | |
| SCHEMBL7242152 | 0.89 | HTR7 (0.49) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL7571721 | 0.88 | POLB (0.47) | SLC6A2DRD4SLC6A4CCR3HTR7 | |
| Bicarbonate SCHEMBL7570498 | 0.87 | MTTP (0.48) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL6219344 | 0.84 | MTTP (0.46) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL6221130 | 0.84 | MTTP (0.54) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL6219359 | 0.84 | MTTP (0.46) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Bicarbonate SCHEMBL7568719 | 0.83 | CCR3 (0.46) | MTTPCHRM2ADRA2AADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | Boehringer Ingelheim Pharma KG (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005762-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-25 | — | — | WO | disclosed |