Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 6/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217316 | 0.91 | POLB (0.45) | POLBHTR7HTR4MCHR1SLC6A2 | |
| SCHEMBL7565332 | 0.90 | HTR7 (0.42) | POLBHTR7HTR4MAOBSLC6A2 | |
| SCHEMBL7570480 | 0.90 | SLC6A12 (0.48) | HTR7HTR4CCR3 | |
| SCHEMBL7565747 | 0.89 | POLB (0.48) | POLBHTR7MCHR1MAOBSLC6A2 | |
| SCHEMBL7242152 | 0.88 | HTR7 (0.49) | HTR7SLC6A2DRD4CCR3 | |
| SCHEMBL7570492 | 0.88 | MTTP (0.47) | HTR7SLC6A2SLC6A4DRD4CCR3 | |
| Bicarbonate SCHEMBL7564901 | 0.87 | POLB (0.48) | POLBHTR7MCHR1MAOBDRD4 | |
| Bicarbonate SCHEMBL7565748 | 0.86 | POLB (0.50) | POLBHTR7HTR4MCHR1MAOB | |
| SCHEMBL7234335 | 0.86 | POLB (0.45) | POLBHTR7HTR4MCHR1SLC6A2 | |
| SCHEMBL7241451 | 0.84 | HTR7 (0.49) | POLBHTR7SLC6A2DRD4CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | Boehringer Ingelheim Pharma KG (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005762-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-25 | — | — | WO | disclosed |