Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.43 |
| ▸ | ITGAV | P06756 | 15/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.39 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565119 | 0.90 | ROCK2 (0.34) | ITGB3ITGAVITGA2B | |
| SCHEMBL7590655 | 0.80 | ITGAV (0.45) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7592208 | 0.80 | ITGAV (0.45) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7552889 | 0.80 | ITGAV (0.45) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7008303 | 0.75 | ITGB3 (0.70) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7008295 | 0.75 | ITGB3 (0.70) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7591261 | 0.74 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7589125 | 0.74 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7575089 | 0.73 | ITGB3 (0.62) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7552205 | 0.71 | ITGAV (0.41) | ITGB3ITGAVITGB5ITGB6ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946165-A4 | INTEGRIN ANTAGONISTS | MERCK & CO INC (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0946165-A1 | INTEGRIN ANTAGONISTS | Merck & Co., Inc. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998018460-A1 | INTEGRIN ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | disclosed |