Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | IDH1 | O75874 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | UBE2N | P61088 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2237430 | 0.87 | ALPL (0.66) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL23832758 | 0.86 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL30218167 | 0.86 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL15661006 | 0.85 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL7580547 | 0.84 | IDH1 (0.71) | SMN1; SMN2L3MBTL1IDH1 | |
| SCHEMBL7571585 | 0.84 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL7571566 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL95317 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL7572373 | 0.84 | L3MBTL1 (0.67) | SMN1; SMN2ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL30927002 | 0.81 | MAPT (0.82) | SMN1; SMN2ALDH1A1LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |